Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors

Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors

Summary: Receptor tyrosine kinases (RTKs) are key players in development and several diseases. Understanding the molecular mechanism of RTK activation by its ligand could lead to the design of new RTK inhibitors. How the extracellular domain is coupled to the intracellular kinase domain is a matter...

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Bibliographic Details
Main Authors: Erik F. Kot, María L. Franco, Ekaterina V. Vasilieva, Alexandra V. Shabalkina, Alexander S. Arseniev, Sergey A. Goncharuk, Konstantin S. Mineev, Marçal Vilar
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Molecular biology
Structural biology
Three-dimensional reconstruction of biomoleculair structures
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006198

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http://www.sciencedirect.com/science/article/pii/S2589004222006198

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