Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1266983/full |
| _version_ | 1827810037686337536 |
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| author | Laura Calvo-Enrique Laura Calvo-Enrique Silvia Lisa Silvia Lisa Cristina Vicente-García Cristina Vicente-García Ruben Deogracias Ruben Deogracias Juan Carlos Arévalo Juan Carlos Arévalo |
| author_facet | Laura Calvo-Enrique Laura Calvo-Enrique Silvia Lisa Silvia Lisa Cristina Vicente-García Cristina Vicente-García Ruben Deogracias Ruben Deogracias Juan Carlos Arévalo Juan Carlos Arévalo |
| author_sort | Laura Calvo-Enrique |
| collection | DOAJ |
| description | Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS) have shown contradictory results. To shed light into this discrepancy, we used a mouse model with a gain-of-function in TrkA receptor signaling. Our results indicate that enhanced TrkA signaling did not alter hippocampal cholinergic innervation, general locomotion or anxiety-related behaviors, but it increases ChAT expression, the number of cholinergic neurons at early postnatal stages and, mutant mice showed impaired motor learning and memory functions. These data demonstrate that proper functioning of the cholinergic system in CNS requires a balanced NGF/TrkA signaling. |
| first_indexed | 2024-03-11T22:48:02Z |
| format | Article |
| id | doaj.art-9b53756f987f4e33894ee4bf6cdd45a2 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-11T22:48:02Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-9b53756f987f4e33894ee4bf6cdd45a22023-09-22T07:30:19ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-09-011610.3389/fnmol.2023.12669831266983Enhanced TrkA signaling impairs basal forebrain-dependent behaviorLaura Calvo-Enrique0Laura Calvo-Enrique1Silvia Lisa2Silvia Lisa3Cristina Vicente-García4Cristina Vicente-García5Ruben Deogracias6Ruben Deogracias7Juan Carlos Arévalo8Juan Carlos Arévalo9Department of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, SpainInstitute of Biomedical Research of Salamanca (IBSAL), Salamanca, SpainDepartment of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, SpainInstitute of Biomedical Research of Salamanca (IBSAL), Salamanca, SpainDepartment of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, SpainInstitute of Biomedical Research of Salamanca (IBSAL), Salamanca, SpainDepartment of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, SpainInstitute of Biomedical Research of Salamanca (IBSAL), Salamanca, SpainDepartment of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, SpainInstitute of Biomedical Research of Salamanca (IBSAL), Salamanca, SpainBasal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS) have shown contradictory results. To shed light into this discrepancy, we used a mouse model with a gain-of-function in TrkA receptor signaling. Our results indicate that enhanced TrkA signaling did not alter hippocampal cholinergic innervation, general locomotion or anxiety-related behaviors, but it increases ChAT expression, the number of cholinergic neurons at early postnatal stages and, mutant mice showed impaired motor learning and memory functions. These data demonstrate that proper functioning of the cholinergic system in CNS requires a balanced NGF/TrkA signaling.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1266983/fullTrkANGF (nerve growth factor)basal forebraincholinergic neuronsmice behaviorlearning |
| spellingShingle | Laura Calvo-Enrique Laura Calvo-Enrique Silvia Lisa Silvia Lisa Cristina Vicente-García Cristina Vicente-García Ruben Deogracias Ruben Deogracias Juan Carlos Arévalo Juan Carlos Arévalo Enhanced TrkA signaling impairs basal forebrain-dependent behavior Frontiers in Molecular Neuroscience TrkA NGF (nerve growth factor) basal forebrain cholinergic neurons mice behavior learning |
| title | Enhanced TrkA signaling impairs basal forebrain-dependent behavior |
| title_full | Enhanced TrkA signaling impairs basal forebrain-dependent behavior |
| title_fullStr | Enhanced TrkA signaling impairs basal forebrain-dependent behavior |
| title_full_unstemmed | Enhanced TrkA signaling impairs basal forebrain-dependent behavior |
| title_short | Enhanced TrkA signaling impairs basal forebrain-dependent behavior |
| title_sort | enhanced trka signaling impairs basal forebrain dependent behavior |
| topic | TrkA NGF (nerve growth factor) basal forebrain cholinergic neurons mice behavior learning |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1266983/full |
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