The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis

The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis

Objective: This study aims to assess the efficacy of the anticatabolic ‘a disintegrin and metalloproteinase with thrombospondin motif-5’ (ADAMTS-5) inhibitor, S201086/GLPG1972, in slowing cartilage loss in participants with knee osteoarthritis (OA). Design: ROCCELLA (NCT03595618) is a randomized, do...

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Bibliographic Details
Main Authors: Olivier Imbert, Henri Deckx, Katy Bernard, Ellen van der Aar, Maria Pueyo, Nadeem Saeed, Thomas Fuerst, Wolfgang Wirth, Philip G. Conaghan, Felix Eckstein
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Knee osteoarthritis
Cartilage
Clinical trial
Disease modification
Quantitative magnetic resonance imaging
ADAMTS-5 inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000728

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http://www.sciencedirect.com/science/article/pii/S2665913121000728

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