Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

Abstract Background It has been shown that tumor microenvironment (TME) hydroxyapatite (HAP) is typically associated with many malignancies and plays a role in tumor progression and growth. Additionally, acidosis in the TME has been reported to play a key role in selecting for a more aggressive tumo...

Full description

Bibliographic Details
Main Authors: Mohammed N. Tantawy, J. Oliver McIntyre, Fiona Yull, M. Wade Calcutt, Dmitry S. Koktysh, Andrew J. Wilson, Zhongliang Zu, Jeff Nyman, Julie Rhoades, Todd E. Peterson, Daniel Colvin, Lisa J. McCawley, Jerri. M. Rook, Barbara Fingleton, Marta Ann Crispens, Ronald D. Alvarez, John C. Gore
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Cancer Medicine
Subjects:
breast cancer
hydroxyapatite
PET
SPECT
tumor extracellular pH
tumor metabolism
Online Access:https://doi.org/10.1002/cam4.6812

Internet

https://doi.org/10.1002/cam4.6812

Similar Items