NR2B antagonist CP-101,606 abolishes pitch-mediated deviance detection in awake rats

NR2B antagonist CP-101,606 abolishes pitch-mediated deviance detection in awake rats

Schizophrenia patients exhibit a decreased ability to detect change in their auditory environment as measured by auditory event related potentials such as mismatch negativity. This deficit has been linked to abnormal NMDA neurotransmission since, among other observations, non-selective channel block...

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Bibliographic Details
Main Authors: Siva eDigavalli, Ping eChen, Yili eYang, Yu-Wen eLi, Rick ePieschl, Michael K Ahlijanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Psychiatry
Subjects:
Ketamine
mismatch negativity (MMN)
NMDA receptor
deviance detection
NR2B subunit
CP-101606
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00096/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00096/full

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