A systems model for immune cell interactions unravels the mechanism of inflammation in human skin.

Inflammation is characterized by altered cytokine levels produced by cell populations in a highly interdependent manner. To elucidate the mechanism of an inflammatory reaction, we have developed a mathematical model for immune cell interactions via the specific, dose-dependent cytokine production ra...

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Bibliographic Details
Main Authors: Najl V Valeyev, Christian Hundhausen, Yoshinori Umezawa, Nikolay V Kotov, Gareth Williams, Alex Clop, Crysanthi Ainali, Christos Ouzounis, Sophia Tsoka, Frank O Nestle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2996319?pdf=render