Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis

Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here, we have examined nucleoside analogues (NAs)...

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Bibliographic Details
Main Authors: Balagra Kasim Sumabe, Synnøve Brandt Ræder, Lisa Marie Røst, Animesh Sharma, Eric S. Donkor, Lydia Mosi, Samuel Duodu, Per Bruheim, Marit Otterlei
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/6/843