Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K<sub>V</sub>10.1 Pore Blockers

Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K<sub>V</sub>10.1 Pore Blockers

The K<sub>V</sub>10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit K<sub>V</sub>10.1, and almost all also inhibit the very similar c...

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Bibliographic Details
Main Authors: Žan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin Mašič, Tihomir Tomašič
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
Eag1
hERG
K<sub>V</sub>10.1 inhibitors
molecular dynamics
pharmacophore
Online Access:https://www.mdpi.com/1422-0067/22/16/8999

Internet

https://www.mdpi.com/1422-0067/22/16/8999

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