Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation

Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation

Summary: Vascular endothelial growth factor receptor-2 (VEGFR2) plays a key role in maintaining vascular endothelial homeostasis. Here, we show that blood flows determine activation and inactivation of VEGFR2 through selective cysteine modifications. VEGFR2 activation is regulated by reversible oxid...

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Bibliographic Details
Main Authors: Dong Hoon Kang, Yerin Kim, Seongchun Min, Su Youn Lee, Ka Young Chung, In-Jeoung Baek, Kihwan Kwon, Hanjoong Jo, Sang Won Kang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013736

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http://www.sciencedirect.com/science/article/pii/S2211124723013736

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