A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and the development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible for the emergence of chemoresistant tumors. Although chemotherapy may initially succeed at...

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Bibliographic Details
Main Authors: Vaishnavi Muralikrishnan, Fang Fang, Tyler C. Given, Ram Podicheti, Mikhail Chtcherbinine, Tara X. Metcalfe, Shruthi Sriramkumar, Heather M. O’Hagan, Thomas D. Hurley, Kenneth P. Nephew
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
ovarian cancer
ALDH1A1
cancer stem cells
senescence
chemotherapy resistance
Online Access:https://www.mdpi.com/2072-6694/14/14/3437

Internet

https://www.mdpi.com/2072-6694/14/14/3437

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