Carbon dots conjugated to SN38 for improved colorectal anticancer therapy

Carbon dots conjugated to SN38 for improved colorectal anticancer therapy

Irinotecan (CTP-11) is one of the standard therapies for colorectal cancer (CRC). CTP-11 is enzymatically converted to the hydrophobic 7-ethyl-10-hydroxycamptothecin (SN38), a one hundred-fold more active metabolite. Conjugation of hydrophobic anticancer drugs to nanomaterials is a strategy to impro...

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Bibliographic Details
Main Authors: Deborah Mattinzoli, Michele Cacioppo, Masami Ikehata, Silvia Armelloni, Carlo Maria Alfieri, Giuseppe Castellano, Mario Barilani, Francesca Arcudi, Piergiorgio Messa, Maurizio Prato
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Bio
Subjects:
Carbon dots
Colorectal cancer therapy
Drug delivery
SN38
Cell cycle
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422000849

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http://www.sciencedirect.com/science/article/pii/S2590006422000849

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