Carbon dots conjugated to SN38 for improved colorectal anticancer therapy
Irinotecan (CTP-11) is one of the standard therapies for colorectal cancer (CRC). CTP-11 is enzymatically converted to the hydrophobic 7-ethyl-10-hydroxycamptothecin (SN38), a one hundred-fold more active metabolite. Conjugation of hydrophobic anticancer drugs to nanomaterials is a strategy to impro...
Main Authors: | Deborah Mattinzoli, Michele Cacioppo, Masami Ikehata, Silvia Armelloni, Carlo Maria Alfieri, Giuseppe Castellano, Mario Barilani, Francesca Arcudi, Piergiorgio Messa, Maurizio Prato |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
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Series: | Materials Today Bio |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000849 |
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