Acute oral toxicity and antimalarial studies of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one in mouse models

Acute oral toxicity and antimalarial studies of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one in mouse models

Reports of resistance to current antimalarial combination therapies (ACTs) have necessitated the discovery of new antimalarial drugs, most importantly with new mechanisms of action. From our molecular docking study, the small molecule 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phe...

Full description

Bibliographic Details
Main Authors: David O Oladejo, Titilope M Dokunmu, Mercy E Tebamifor, Mercy B Omunagbe, Esther O Okafor, Emeka EJ Iweala
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Scientific African
Subjects:
Malaria
Malaria parasites
Drug discovery
Small molecules
Toxicity
Parasite suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227624001406

Internet

http://www.sciencedirect.com/science/article/pii/S2468227624001406

Similar Items