PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-inter...

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Bibliographic Details
Main Authors: Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Cancer
Subjects:
PI3K/AKT/mTORC pathway
Pan PI3K inhibitors
Isoform-specific PI3K inhibitors
Dual PI3K/mTOR inhibitors
AKT inhibitors
Allosteric mTOR inhibitors
Online Access:https://doi.org/10.1186/s12943-023-01827-6

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https://doi.org/10.1186/s12943-023-01827-6

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