SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging. In this study, we reveal that male <i>Sirt7</i> knockout (KO) mice exhibited an extension...

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Bibliographic Details
Main Authors: Tomoya Mizumoto, Tatsuya Yoshizawa, Yoshifumi Sato, Takaaki Ito, Tomonori Tsuyama, Akiko Satoh, Satoshi Araki, Kenichi Tsujita, Masaru Tamura, Yuichi Oike, Kazuya Yamagata
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
SIRT7
knockout mouse
lifespan
FGF21
Online Access:https://www.mdpi.com/2073-4409/11/22/3609

Internet

https://www.mdpi.com/2073-4409/11/22/3609

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