Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, little is known regarding the effects of prolonged...

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Bibliographic Details
Main Authors: Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Metabolism
Subjects:
Diabetes
Polyol pathway
Liver carbohydrate metabolism
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000880

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http://www.sciencedirect.com/science/article/pii/S2212877821000880

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