Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1

Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1

Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation. However, the underlying molecular mechanism is poorly understood. Using an in vitro vascular ce...

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Bibliographic Details
Main Authors: Sa Zhou, Jiamin Xue, Jingbo Shan, Yingxiang Hong, Wenkang Zhu, Zhiyan Nie, Yujie Zhang, Nanxi Ji, Xuegang Luo, Tongcun Zhang, Wenjian Ma
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Nutrients
Subjects:
TMAO
ROS
inflammation
gut microbiota
choline
atherosclerosis
Online Access:https://www.mdpi.com/2072-6643/14/16/3338

Internet

https://www.mdpi.com/2072-6643/14/16/3338

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