The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161067/full |
| _version_ | 1827931028963983360 |
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| author | Valentina Carlini Douglas M. Noonan Douglas M. Noonan Eslam Abdalalem Delia Goletti Clementina Sansone Luana Calabrone Adriana Albini |
| author_facet | Valentina Carlini Douglas M. Noonan Douglas M. Noonan Eslam Abdalalem Delia Goletti Clementina Sansone Luana Calabrone Adriana Albini |
| author_sort | Valentina Carlini |
| collection | DOAJ |
| description | Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions. Given the pivotal role of IL-10 in immune modulation, this cytokine could have relevant implications in pathologies characterized by hyperinflammatory state, such as cancer, or infectious diseases as in the case of COVID-19 and Post-COVID-19 syndrome. Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation. Pharmacological strategies aimed to potentiate or restore IL-10 immunomodulatory action may represent novel promising avenues to counteract cytokine storm arising from hyperinflammation and effectively mitigate severe complications. Natural bioactive compounds, derived from terrestrial or marine photosynthetic organisms and able to increase IL-10 expression, could represent a useful prevention strategy to curb inflammation through IL-10 elevation and will be discussed here. However, the multifaceted nature of IL-10 has to be taken into account in the attempts to modulate its levels. |
| first_indexed | 2024-03-13T06:45:49Z |
| format | Article |
| id | doaj.art-9b6d1a7747024ee2b5c3202d7f9476e1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T06:45:49Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9b6d1a7747024ee2b5c3202d7f9476e12023-06-08T06:08:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11610671161067The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditionsValentina Carlini0Douglas M. Noonan1Douglas M. Noonan2Eslam Abdalalem3Delia Goletti4Clementina Sansone5Luana Calabrone6Adriana Albini7Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), MultiMedica, Milan, ItalyIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), MultiMedica, Milan, ItalyDepartment of Biotechnology and Life Sciences, University of Insubria, Varese, ItalyIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), MultiMedica, Milan, ItalyTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani- Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, ItalyStazione Zoologica Anton Dohrn, Istituto Nazionale di Biologia, Ecologia e Biotecnologie Marine, Napoli, ItalyIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), MultiMedica, Milan, ItalyIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) European Institute of Oncology IEO-, Milan, ItalyInterleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions. Given the pivotal role of IL-10 in immune modulation, this cytokine could have relevant implications in pathologies characterized by hyperinflammatory state, such as cancer, or infectious diseases as in the case of COVID-19 and Post-COVID-19 syndrome. Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation. Pharmacological strategies aimed to potentiate or restore IL-10 immunomodulatory action may represent novel promising avenues to counteract cytokine storm arising from hyperinflammation and effectively mitigate severe complications. Natural bioactive compounds, derived from terrestrial or marine photosynthetic organisms and able to increase IL-10 expression, could represent a useful prevention strategy to curb inflammation through IL-10 elevation and will be discussed here. However, the multifaceted nature of IL-10 has to be taken into account in the attempts to modulate its levels.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161067/fullIL-10STAT3cytokine stormalarminCOVID - 19Post-COVID |
| spellingShingle | Valentina Carlini Douglas M. Noonan Douglas M. Noonan Eslam Abdalalem Delia Goletti Clementina Sansone Luana Calabrone Adriana Albini The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions Frontiers in Immunology IL-10 STAT3 cytokine storm alarmin COVID - 19 Post-COVID |
| title | The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions |
| title_full | The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions |
| title_fullStr | The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions |
| title_full_unstemmed | The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions |
| title_short | The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions |
| title_sort | multifaceted nature of il 10 regulation role in immunological homeostasis and its relevance to cancer covid 19 and post covid conditions |
| topic | IL-10 STAT3 cytokine storm alarmin COVID - 19 Post-COVID |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161067/full |
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