Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-a...

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Bibliographic Details
Main Authors: Kazue Hisaoka-Nakashima, Honami Azuma, Fumina Ishikawa, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
stress
glucocorticoid
HMGB1
astrocyte
neuroinflammation
major depressive disorder
Online Access:https://www.mdpi.com/2073-4409/9/5/1068

Internet

https://www.mdpi.com/2073-4409/9/5/1068

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