Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner

Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner

LRRK2 (leucine-rich repeat kinase 2) has been identified as agene corresponding to PARK8, an autosomal-dominant genefor familial Parkinson’s disease (PD). LRRK2 pathogenicspecificmutants induce neurotoxicity and shorten neurites. Toelucidate the mechanism underlying LRRK2 expression, weconstructed t...

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Bibliographic Details
Main Authors: Ji-Min Park, Dong-Hwan Ho, Hye Jin Yun, Hye-Jung Kim, Chan Hong Lee, Sung Woo Park, Young Hoon Kim, Ilhong Son, Wongi Seol
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2013-09-01
Series:BMB Reports
Subjects:
α-Synuclein
Dexamethasone
Glucocorticoid receptor(GR)
LRRK2
Parkinson’s disease
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTcyN18lMjg0NTQtNDU5JTI5Qk1CXzEyLTIzNC5wZGY=

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http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTcyN18lMjg0NTQtNDU5JTI5Qk1CXzEyLTIzNC5wZGY=

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