Histone depletion prevents telomere fusions in pre-senescent cells.

Histone depletion prevents telomere fusions in pre-senescent cells.

Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during pre-senescence by preventing telomere-telomere fusions (T-TFs) and the subsequent genet...

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Bibliographic Details
Main Authors: Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M Muñoz-Cabello, Félix Prado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Genetics
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pgen.1007407/1/pgen.1007407.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T101059Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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