Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype

Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype

Abstract Background Acute myeloid leukemia (AML) patients with normal karyotype (NK-AML) have significant variabilities in outcomes. The European Leukemia Net stratification system and some prognostic models have been used to evaluate risk stratification. However, these common standards still have s...

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Bibliographic Details
Main Authors: Yu Liu, Yufei Chen, Yajun Liu, Mengya Li, Yu Zhang, Luyao Shi, Lu Yang, Tao Li, Yafei Li, Zhongxing Jiang, Yanfang Liu, Chong Wang, Shujuan Wang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Acute myeloid leukemia
Prognosis
SMIM3
Cell proliferation
Cell cycle
PI3K-AKT
Online Access:https://doi.org/10.1186/s12967-022-03831-8

Internet

https://doi.org/10.1186/s12967-022-03831-8

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