Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors

Background: Heat shock protein 90 (HSP90) is a well-known target for cancer therapy. In a previous work, some of us have reported a series of 3-aryl-naphtho[2,3-d]isoxazole-4,9-diones as inhibitors of HSP90. Methods: In the present work, various compounds with new chromenopyridinone and thiochromeno...

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Bibliographic Details
Main Authors: Ana Bizarro, Diana Sousa, Raquel T. Lima, Loana Musso, Raffaella Cincinelli, Vantina Zuco, Michelandrea De Cesare, Sabrina Dallavalle, M. Helena Vasconcelos
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
HSP90
naphthoquinones
(thio)chromenopyridinones
antitumor
cell proliferation
cell cycle
apoptosis
tumor xenographs
Online Access:http://www.mdpi.com/1420-3049/23/2/407

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http://www.mdpi.com/1420-3049/23/2/407

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