A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report

A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report

Abstract Background High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited published data on UPSs suggest an aggressive clinical course, high rates o...

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Bibliographic Details
Main Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang, Luying Liu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
Undifferentiated pleomorphic sarcoma
Spindle cells
Lumbosacral
LMNA-NTRK1 gene fusion
Crizotinib therapy
Online Access:http://link.springer.com/article/10.1186/s12885-018-4749-z

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http://link.springer.com/article/10.1186/s12885-018-4749-z

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