Treatment response to spironolactone in patients with heart failure with preserved ejection fraction: a machine learning-based analysis of two randomized controlled trialsResearch in context

Summary: Background: Whether there is a subset of patients with heart failure with preserved ejection fraction (HFpEF) that benefit from spironolactone therapy is unclear. We applied a machine learning approach to identify responders and non-responders to spironolactone among patients with HFpEF in...

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Bibliographic Details
Main Authors: Karl-Patrik Kresoja, Matthias Unterhuber, Rolf Wachter, Karl-Philipp Rommel, Christian Besler, Sanjiv Shah, Holger Thiele, Frank Edelmann, Philipp Lurz
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003614