IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19

IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19

Acute respiratory distress syndrome (ARDS) in COVID-19 has been associated with catastrophic inflammation. We present measurements in humans and a new animal model implicating a role in danger-associated molecular patterns. Calprotectin (S100A8/A9) and high-mobility group box 1 (HMGB1) were measured...

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Bibliographic Details
Main Authors: Georgios Renieris, Eleni Karakike, Theologia Gkavogianni, Dionysia-Eirini Droggiti, Emmanouil Stylianakis, Theano Andriopoulou, Victoria-Marina Spanou, Dionyssios Kafousopoulos, Mihai G. Netea, Jesper Eugen-Olsen, John Simard, Evangelos J. Giamarellos-Bourboulis
Format: Article
Language:English
Published: Karger Publishers 2022-05-01
Series:Journal of Innate Immunity
Subjects:
calprotectin
tumor necrosis factor
interleukin-6
interleukin-1
soluble urokinase plasminogen activator receptor
acute respiratory distress syndrome
severe respiratory failure
coronavirus diseases 2019
Online Access:https://www.karger.com/Article/FullText/524560

Internet

https://www.karger.com/Article/FullText/524560

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