TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer

TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC is highly immunosuppressive and desmoplastic, whic...

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Bibliographic Details
Main Authors: Marco Donia, Mads Hald Andersen, Lars Grøntved, Daniel Hargbøl Madsen, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum, Lucia Lara de la Torre, Simone Kloch Bendtsen
Format: Article
Language:English
Published: BMJ Publishing Group 2022-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/12/e005491.full

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https://jitc.bmj.com/content/10/12/e005491.full

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