Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity

Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity

Summary: Elimination of self-reactive T cells in the thymus is critical to establish T-cell tolerance. A growing body of evidence suggests a role for thymic B cells in the elimination of self-reactive thymocytes. To specifically address the role of thymic B cells in central tolerance, we investigate...

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Bibliographic Details
Main Authors: Félix Lombard-Vadnais, Geneviève Chabot-Roy, Astrid Zahn, Sahily Rodriguez Torres, Javier M. Di Noia, Heather J. Melichar, Sylvie Lesage
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Immunology
Immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222021253

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http://www.sciencedirect.com/science/article/pii/S2589004222021253

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