Exploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations

Exploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations

The Src homology-2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2, encoded by PTPN11) is a critical allosteric phosphatase for many signaling pathways. Programmed cell death 1 (PD-1) could be phosphorylated at its immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor...

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Bibliographic Details
Main Authors: Quan Wang, Wen-Cheng Zhao, Xue-Qi Fu, Qing-Chuan Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Chemistry
Subjects:
SHP2
PD-1
MD simulations
allosteric
PCA
motion modes
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.597495/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.597495/full

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