Hereditary Breast and Ovarian Cancer in Families from Southern Italy (Sicily)—Prevalence and Geographic Distribution of Pathogenic Variants in <i>BRCA1/2</i> Genes

Hereditary Breast and Ovarian Cancer in Families from Southern Italy (Sicily)—Prevalence and Geographic Distribution of Pathogenic Variants in <i>BRCA1/2</i> Genes

Recent advances in the detection of germline pathogenic variants (PVs) in <i>BRCA1/2</i> genes have allowed a deeper understanding of the <i>BRCA</i>-related cancer risk. Several studies showed a significant heterogeneity in the prevalence of PVs across different populations....

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Bibliographic Details
Main Authors: Lorena Incorvaia, Daniele Fanale, Giuseppe Badalamenti, Marco Bono, Valentina Calò, Daniela Cancelliere, Marta Castiglia, Alessia Fiorino, Alessia Pivetti, Nadia Barraco, Sofia Cutaia, Antonio Russo, Viviana Bazan
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
<i>BRCA1</i>
<i>BRCA2</i>
breast cancer
founder variants
genetic testing
germline pathogenic variants
Online Access:https://www.mdpi.com/2072-6694/12/5/1158

Internet

https://www.mdpi.com/2072-6694/12/5/1158

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