BRD4 promotes resection and homology-directed repair of DNA double-strand breaks

BRD4 promotes resection and homology-directed repair of DNA double-strand breaks

BRD4 is a multifunctional regulator of chromatin binding that plays a direct role in DNA double-strand break repair. BRD4 interacts with the SWI/SNF chromatin remodeling complex and resection machinery to promote homologous recombination.

Bibliographic Details
Main Authors: John K. Barrows, Baicheng Lin, Colleen E. Quaas, George Fullbright, Elizabeth N. Wallace, David T. Long
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30787-6

Internet

https://doi.org/10.1038/s41467-022-30787-6

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