IFN-γ immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans.

IFN-γ immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans.

Development of vaccines against opportunistic infections is difficult as patients most at risk of developing disease are deficient in aspects of the adaptive immune system. Here, we utilized an experimental immunization strategy to induce innate memory in macrophages in vivo. Unlike current trained...

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Bibliographic Details
Main Authors: Chrissy M Leopold Wager, Camaron R Hole, Althea Campuzano, Natalia Castro-Lopez, Hong Cai, Marley C Caballero Van Dyke, Karen L Wozniak, Yufeng Wang, Floyd L Wormley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007358

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https://doi.org/10.1371/journal.ppat.1007358

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