Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy

[INLINE:1] Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease...

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Bibliographic Details
Main Authors: Bismark Gatica-Garcia, Michael J Bannon, Irma Alicia Martínez-Dávila, Luis O Soto-Rojas, David Reyes-Corona, Lourdes Escobedo, Minerva Maldonado-Berny, ME Gutierrez-Castillo, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan U Mascotte-Cruz, CP Rodríguez-Oviedo, Irais E Valenzuela-Arzeta, Claudia Luna-Herrera, Francisco E Lopez-Salas, Jaime Santoyo-Salazar, Daniel Martinez-Fong
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
a1 astrocytes; a2 astrocytes; gene therapy; microglia; motor deficits; nanoparticles; neurodegeneration; neuroinflammation; senescence; α-synuclein aggregates
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=9;spage=2057;epage=2067;aulast=

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=9;spage=2057;epage=2067;aulast=

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