Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

<i>N</i>1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a chalcone reaction with differen...

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Bibliographic Details
Main Authors: Bhupender S. Chhikara, Sajda Ashraf, Saghar Mozaffari, Nicole St. Jeans, Dindyal Mandal, Rakesh Kumar Tiwari, Zaheer Ul-Haq, Keykavous Parang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
protein kinase
phenylpyrazolopyrimidine
antiproliferative activity
enzyme inhibition
molecular simulation
Online Access:https://www.mdpi.com/1420-3049/25/9/2135

Internet

https://www.mdpi.com/1420-3049/25/9/2135

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