Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation

Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation

TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) is an immunoreceptor expressed on neutrophils, monocytes/macrophages, and endothelial cells. It amplifies the inflammatory response driven by Toll-Like Receptors (TLR) engagement. The pharmacological inhibition of TREM-1 confers protection in...

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Bibliographic Details
Main Authors: Sébastien Gibot, Lucie Jolly, Jérémie Lemarié, Kevin Carrasco, Marc Derive, Amir Boufenzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
sepsis
inflammation
TREM-1
endothelium
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02314/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02314/full

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