The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

Abstract Background The gut microbiota can affect neurologic disease by shaping microglia, the primary immune cell in the central nervous system (CNS). While antibiotics improve models of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and the C9orf72 model of amyotrophic lateral scler...

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Bibliographic Details
Main Authors: Laura M. Cox, Narghes Calcagno, Christian Gauthier, Charlotte Madore, Oleg Butovsky, Howard L. Weiner
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Microbiome
Online Access:https://doi.org/10.1186/s40168-022-01232-z