Gabapentin Increases Intra-Epidermal and Peptidergic Nerve Fibers Density and Alleviates Allodynia and Thermal Hyperalgesia in a Mouse Model of Acute Taxol-Induced Peripheral Neuropathy

Gabapentin Increases Intra-Epidermal and Peptidergic Nerve Fibers Density and Alleviates Allodynia and Thermal Hyperalgesia in a Mouse Model of Acute Taxol-Induced Peripheral Neuropathy

The clinical pathology of Taxol-induced peripheral neuropathy (TIPN), characterized by loss of sensory sensitivity and pain, is mirrored in a preclinical pharmacological mice model in which Gabapentin, produced anti-thermal hyperalgesia and anti-allodynia effects. The study aimed to investigate the...

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Bibliographic Details
Main Authors: Michal Klazas, Majdi Saleem Naamneh, Wenhua Zheng, Philip Lazarovici
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomedicines
Subjects:
Taxol-induced peripheral neuropathy (TIPN)
intra-epidermal nerve fibers (IENF)
calcitonin gene-related peptides (CGRP)
gabapentin (Neurontin)
neuropathic pain
analgesia
Online Access:https://www.mdpi.com/2227-9059/10/12/3190

Internet

https://www.mdpi.com/2227-9059/10/12/3190

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