Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody

Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody

Regulatory T cells (T<sub>regs</sub>) are major drivers behind immunosuppressive mechanisms and present a major hurdle for cancer therapy. T<sub>regs</sub> are characterized by a high expression of CD25, which is a potentially valuable target for T<sub>reg</sub> d...

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Bibliographic Details
Main Authors: Marit J. van Elsas, Johan M. S. van der Schoot, Alexander Bartels, Kas Steuten, Duco van Dalen, Zacharias Wijfjes, Carl G. Figdor, Thorbald van Hall, Sjoerd H. van der Burg, Martijn Verdoes, Ferenc A. Scheeren
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
antibody
immunotherapy
CRISPR-HDR
Fc optimization
hybridoma
Online Access:https://www.mdpi.com/1422-0067/23/15/8707

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