Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

<p>Abstract</p> <p>Background</p> <p>The RNA-dependent RNA polymerase of Influenza A virus is a determinant of viral pathogenicity and host range that is responsible for transcribing and replicating the negative sense segmented viral genome (vRNA). Transcription produce...

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Bibliographic Details
Main Authors: Tiley Laurence S, Medcalf Elizabeth, Amorim Maria, Mullin Anne E, Dalton Rosa M, Digard Paul
Format: Article
Language:English
Published: BMC 2006-08-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/3/1/58