Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells

Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells

Abstract Background The most significant cause of treatment failure in chronic myeloid leukemia (CML) is a persistent population of minimal residual cells. Emerging evidences showed that methylation of SHP-1 contributed to Imatinib (IM) resistance. Baicalein was reported to have an effect on reversa...

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Bibliographic Details
Main Authors: Xuefen Xu, Shufan Ji, Yuan Chen, Siwei Xia, Yang Li, Li Chen, Yujia Li, Feng Zhang, Zili Zhang, Shizhong Zheng
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
CML CD34+ cells
DNMT1
SHP-1
Resistance
Baicalein
Online Access:https://doi.org/10.1186/s12964-023-01049-9

Internet

https://doi.org/10.1186/s12964-023-01049-9

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