Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found in malignant brain tumors highlighting their important roles as oncogenes. Brain tumors in children are the most lethal of all pediatric malignancies and the most common malignant primary adult brain...

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Bibliographic Details
Main Authors: Anna Borgenvik, Matko Čančer, Sonja Hutter, Fredrik J. Swartling
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
MYCN
brain tumor
targeted therapies
c-MYC
OCT4
medulloblastoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.626751/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.626751/full

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