The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis

The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis

Abstract Background Transforming Growth Factor-β1 (TGF-β1) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β1 are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function. Aim The aim of this study was...

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Bibliographic Details
Main Authors: T. Trojan, Miguel A. Alejandre Alcazar, G. Fink, J. C. Thomassen, M. V. Maessenhausen, E. Rietschel, P. M. Schneider, S. van Koningsbruggen-Rietschel
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Pulmonary Medicine
Subjects:
Transforming-growth-factor Beta 1 (TGF-β1)
Cystic fibrosis
Polymorphisms
Inflammation
Forced expiratory volume in one second (FEV1)
Pseudomonas aeruginosa
Online Access:https://doi.org/10.1186/s12890-022-01977-1

Internet

https://doi.org/10.1186/s12890-022-01977-1

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