Relevance of AIF/CypA Lethal Pathway in SH-SY5Y Cells Treated with Staurosporine

Relevance of AIF/CypA Lethal Pathway in SH-SY5Y Cells Treated with Staurosporine

The AIF/CypA complex exerts a lethal activity in several rodent models of acute brain injury. Upon formation, it translocates into the nucleus of cells receiving apoptotic stimuli, inducing chromatin condensation, DNA fragmentation, and cell death by a caspase-independent mechanism. Inhibition of th...

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Bibliographic Details
Main Authors: Mariarosaria Conte, Rosanna Palumbo, Alessandra Monti, Elisabetta Fontana, Angela Nebbioso, Menotti Ruvo, Lucia Altucci, Nunzianna Doti
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cyclophilin A (CypA)
apoptosis-inducing factor (AIF)
human neuroblastoma SH-SY5Y cells
staurosporine-mediated cell death
AIF(370-394) peptide
caspase-3
Online Access:https://www.mdpi.com/1422-0067/23/1/265

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https://www.mdpi.com/1422-0067/23/1/265

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