FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair

FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair

Abstract Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor...

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Detaylı Bibliyografya
Asıl Yazarlar: Shu-Ping Wang, Shi-Qi Wu, Shi-Hui Huang, Yi-Xuan Tang, Liu-Qiong Meng, Feng Liu, Qi-Hua Zhu, Yun-Gen Xu
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Nature Publishing Group 2021-12-01
Seri Bilgileri:Cell Death and Disease
Online Erişim:https://doi.org/10.1038/s41419-021-04434-9

Internet

https://doi.org/10.1038/s41419-021-04434-9

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