Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer’s disease mouse model

Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer’s disease mouse model

IntroductionAlzheimer’s disease (AD) is characterized by increasing cognitive dysfunction, progressive cerebral amyloid beta (Aβ) deposition, and neurofibrillary tangle aggregation. However, the molecular mechanisms of AD pathologies have not been completely understood. As synaptic glycoprotein neur...

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Bibliographic Details
Main Authors: Dan-Dan Wu, Jie Cheng, Ya-Ni Zheng, Yu-Tong Liu, Shuang-Xin Hou, Li-Fen Liu, Liang Huang, Qiong-Lan Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroplastin 65
Alzheimer’s disease
amyloid plaques
neuroinflammation
5-hydroxytryptamine receptor 3A subunit
glial activation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1129773/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1129773/full

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