A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM]

A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM]

Abstract Background MGMT (O 6 -methylguanine-DNA methyltransferase) promoter methylation is a commonly assessed prognostic marker in glioblastoma (GBM). Epigenetic silencing of the MGMT gene by promoter methylation is associated with greater overall and progression free survival with alkylating agen...

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Bibliographic Details
Main Authors: David Gibson, Anh Huan Vo, Hannah Lambing, Prithanjan Bhattacharya, Peggy Tahir, Farid F. Chehab, Nicholas Butowski
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Neurology
Subjects:
MGMT
Methylation
Glioblastoma
CpG
Epigenetics
Online Access:https://doi.org/10.1186/s12883-024-03605-3

Internet

https://doi.org/10.1186/s12883-024-03605-3

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