Sertindole inhibits autophagic flux and glioma progression

Sertindole inhibits autophagic flux and glioma progression

Abstract Gliomas, the most lethal brain tumors, often exhibit resistance to conventional chemotherapy and/or radiotherapy. This study reveals that sertindole, a potent dopamine D2 receptor antagonist primarily designed as an antipsychotic medication for schizophrenia, effectively inhibits glioma pro...

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Bibliographic Details
Main Authors: Baiyang Liu, Yulin Shi, Bo Qin, Dating Cheng, Zhi Nie, Haoqing Zhai, Yao Li, Zhixian Jin, Jun Pu, Dongming Yan, Yongbin Chen, Cuiping Yang
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:MedComm – Oncology
Subjects:
autophagic flux
cell proliferation
gliomas
sertindole
stemness maintenance
temozolomide
Online Access:https://doi.org/10.1002/mog2.41

Internet

https://doi.org/10.1002/mog2.41

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