Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

Context: Direct evidence of Triphala-drug interactions has not been provided to date. Objective: This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) in vitro, and to investigate pharmacokinetic interactions of Triphala with CYP-probes...

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Bibliographic Details
Main Authors: Jannarin Nontakham, Pongpun Siripong, Hitoshi Sato, Savita Chewchinda, Kuntarat Arunrungvichian, Jantana Yahuafai, Arman Syah Goli, Vilasinee Hirunpanich Sato
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Heliyon
Subjects:
Pharmacokinetic interaction
Triphala extract
Cytochrome P450
P-glycoprotein
Phenacetin
Midazolam
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022010520

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http://www.sciencedirect.com/science/article/pii/S2405844022010520

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