Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Engineering brain organoids from human induced pluripotent stem cells (hiPSCs) is a powerful tool for modeling brain development and neurological disorders. Rett syndrome (RTT), a rare neurodevelopmental disorder, can greatly benefit from this technology, since it affects multiple neuronal subtypes...

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Bibliographic Details
Main Authors: Ana Rita Gomes, Tiago G. Fernandes, Sandra H. Vaz, Teresa P. Silva, Evguenia P. Bekman, Sara Xapelli, Sofia Duarte, Mehrnaz Ghazvini, Joost Gribnau, Alysson R. Muotri, Cleber A. Trujillo, Ana M. Sebastião, Joaquim M. S. Cabral, Maria Margarida Diogo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
human induced pluripotent stem cells
organoids
forebrain
Rett syndrome
disease modeling
neurodevelopmental disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.610427/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.610427/full

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