Evaluation of the immunogenicity of auxotrophic Lactobacillus with CRISPR-Cas9D10A system-mediated chromosomal editing to express porcine rotavirus capsid protein VP4

Evaluation of the immunogenicity of auxotrophic Lactobacillus with CRISPR-Cas9D10A system-mediated chromosomal editing to express porcine rotavirus capsid protein VP4

Porcine rotavirus (PoRV) is an important pathogen, leading to the occurrence of viral diarrhoea . As the infection displays obvious enterotropism, intestinal mucosal immunity is the significant line of defence against pathogen invasion. Moreover, as lactic acid bacteria (LAB) show acid resistance, b...

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Bibliographic Details
Main Authors: Fengsai Li, Zhuyuan Mei, Ning Ju, Ling Sui, Xiaolong Fan, Zi Wang, Jiaxuan Li, Yanping Jiang, Wen Cui, Zhifu Shan, Han Zhou, Li Wang, Xinyuan Qiao, Lijie Tang, Xiaona Wang, Yijing Li
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Virulence
Subjects:
Lactobacillus
auxotrophic
alanine racemase
CRISPR-Cas9D10A
PoRV
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2022.2107646

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https://www.tandfonline.com/doi/10.1080/21505594.2022.2107646

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